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KMID : 0378019780210020144
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New Medical Journal
1978 Volume.21 No. 2 p.144 ~ p.150
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Response of the Isolated Nonpregnant Rabbit Uterus to Autonomic Drugs
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Abstract
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It has been generally understood that the responses of uterine muscle to autonomic drugs, especially to norepinephrine, vary with species, phase of the sexual cycle, state of gestation, and the dose given or even with individuals in one species. There are other arguments whether the uterus really receives autonomic nerve innervation and what is the physiological significance of the autonomic innervation. In order to investigate the effect of various autonomic drugs on the nonpregnant rabbit uterus, the responses of the isolated rabbit uterine segment to some autonomic nerve stimulants and their blocking agents were observed using the kymography. A excitatory response was evoked by the administration of acetylcholine and the effect was completely abolished by pretreatment with atropine, a cholinergic blocking agent. Administration of norepinephrine elicited various responses according to individuals; contraction, relaxation or inhibition of spontaneous activities of the uterine segment. The contractile response was abolished and changed to relaxation or inhibition of the spontaneous contraction by pretreatment with dibenamine or phenoxybenzamine, a ?-adrenergic blocking agent, while the response was not markedly decreased by pretreatment with propranolol or atropine. The inhibitory response was not affected by pretreatment with dibenamine or phenoxybenzamine, and the propranolol pretreatment caused the decreasing effect of norepinephrine, however, the spontaneous activity still reduced markedly. Administration of isoproterenol caused either a marked inhibition of the spontaneous activities or a relaxation. The responses were not affected by pretreatment with dibenamine and were not completely blocked by pretreatment with propranolol, a ?-adrenergic blocking agent.
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